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Naltrexone was first made in 1965 and was approved for medical use in the United States in 1984. Dosage is based on your medical condition and response to treatment. Your doctor may start you at a lower dose and monitor you for any side effects or withdrawal symptoms before increasing your dose. A decreased desire for opioids, though, may take a few weeks. Before having surgery or any medical treatment, tell your doctor or dentist that you are taking this medication. Naltrexone has been shown to decrease the amount and frequency of drinking. Your doctor may start you at a lower dose and monitor you for any side effects or withdrawal symptoms before increasing your dose. When naltrexone is taken in a clinic or treatment center, it may be taken once a day, once every other day, once every third day, or once every day except Sunday. If withdrawal occurs, naltrexone should not be started. Your doctor may occasionally change your dose to make sure you get the best results. Before taking naltrexone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Your doctor may recommend that naltrexone be given to you by a family member or other caregiver. Using the same amount you used before could lead to overdose or death.

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