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Before having surgery or any medical treatment, tell your doctor or dentist that you are taking this medication. It has benefits over methadone and buprenorphine in that it is not a restricted medication. Naltrexone may cause liver damage when taken in large doses. Do not take more or less of it or take it more often than prescribed by your doctor. Use naltrexone regularly to get the most benefit. During pregnancy, this medication should be used only when clearly needed. To help you remember, take it at the same time each day. A decreased desire for opioids, though, may take a few weeks. Use is not recommended in people with liver failure. Due to this issue, the usefulness of oral naltrexone in opioid use disorders is limited by the low retention in treatment. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Use naltrexone regularly to get the most benefit. This is to make sure you are using the medicine as it was prescribed as part of your treatment. The most common side effects reported with naltrexone are gastrointestinal complaints such as diarrhea and abdominal cramping.

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