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Take this medication by mouth with or without food, usually 50 milligrams once daily or as directed by your doctor. Do not take more or less of it or take it more often than prescribed by your doctor. Some physicians use a naloxone challenge to determine whether an individual has any opioids remaining. Naltrexone comes as a tablet to take by mouth either at home or under supervision in a clinic or treatment center. It works in the brain to prevent opiate effects (e.g., feelings of well-being, pain relief). Naltrexone is used as part of a treatment program for drug or alcohol dependence. Use naltrexone regularly to get the most benefit. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Your doctor may occasionally change your dose to make sure you get the best results. Side effects may include trouble sleeping, anxiety, nausea, and headaches. If withdrawal occurs, naltrexone should not be started. Your doctor may recommend that naltrexone be given to you by a family member or other caregiver. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.

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