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A decreased desire for opioids, though, may take a few weeks. Trying to overcome this block is very dangerous and may cause serious injury, loss of consciousness, and death. After taking naltrexone, your body will be more sensitive to opioids. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Naltrexone may be taken with food if it upsets your stomach. In those still on opioids, opioid withdrawal may occur. It may decrease cravings for opioids after a number of weeks, and decreases the risk of overdose. The time of abstinence may be shorter than 7 days, depending on the half-life of the specific opioid taken. In this case, your doctor may order a higher dose (100-150 milligrams) to be taken every 2-3 days to make it easier to schedule clinic visits. Follow your doctor's instructions closely. A combination of naltrexone with buprenorphine (buprenorphine/naltrexone) has been developed, but has not been marketed. If withdrawal occurs, naltrexone should not be started. Naltrexone comes as a tablet to take by mouth either at home or under supervision in a clinic or treatment center. Concerns for liver toxicity initially arose from a study of nonaddicted obese patients receiving 300 mg of naltrexone.

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