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This medication is used to prevent people who have been addicted to certain drugs (opiates) from taking them again. Due to this issue, the usefulness of oral naltrexone in opioid use disorders is limited by the low retention in treatment. However, large doses of heroin or narcotics can overcome this block. In this case, your doctor may order a higher dose (100-150 milligrams) to be taken every 2-3 days to make it easier to schedule clinic visits. Follow your doctor's instructions closely. Subsequent studies have suggested limited toxicity in other patient populations. Your doctor may occasionally change your dose to make sure you get the best results. You may need to stop certain opiate drugs (such as methadone) 10 to 14 days before starting naltrexone. During pregnancy, this medication should be used only when clearly needed. Trying to overcome this block is very dangerous and may cause serious injury, loss of consciousness, and death. Naltrexone is used to prevent relapse in people who became dependent on opioid medicine and then stopped using it. Naltrexone should not be started until several (typically 7-10) days of abstinence from opioids have been achieved. Naltrexone is also used to treat alcoholism by reducing your urge to drink alcohol. A combination of naltrexone with buprenorphine (buprenorphine/naltrexone) has been developed, but has not been marketed.

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